Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction

@article{Huang2004RollingBA,
  title={Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction},
  author={Fu-De Huang and Heinrich J. G. Matthies and Sean D. Speese and Mark A. Smith and Kendal Broadie},
  journal={Nature Neuroscience},
  year={2004},
  volume={7},
  pages={1070-1078}
}
The rolling blackout (rbo) gene encodes an integral plasma membrane lipase required for Drosophila phototransduction. Photoreceptors are enriched for the RBO protein, and temperature-sensitive rbo mutants show reversible elimination of phototransduction within minutes, demonstrating an acute requirement for the protein. The block is activity dependent, indicating that the action of RBO is use dependent. Conditional rbo mutants show activity-dependent depletion of diacylglycerol and concomitant… CONTINUE READING
29 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Cloning of the first sn 1 - DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

  • T. Bisogno
  • J . Cell Biol .
  • 2003

Similar Papers

Loading similar papers…