Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.

@article{Barad1998RolipramAT,
  title={Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.},
  author={Mark Barad and Rusiko Bourtchouladze and Danny G. Winder and Hava Golan and Eric Kandel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 25},
  pages={15020-5}
}
In an attempt to improve behavioral memory, we devised a strategy to amplify the signal-to-noise ratio of the cAMP pathway, which plays a central role in hippocampal synaptic plasticity and behavioral memory. Multiple high-frequency trains of electrical stimulation induce long-lasting long-term potentiation, a form of synaptic strengthening in hippocampus that is greater in both magnitude and persistence than the short-lasting long-term potentiation generated by a single tetanic train. Studies… CONTINUE READING
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