Roles of white matter in central nervous system pathophysiologies

  title={Roles of white matter in central nervous system pathophysiologies},
  author={Carlos Matute and Bruce R Ransom},
  booktitle={ASN neuro},
The phylogenetic enlargement of cerebral cortex culminating in the human brain imposed greater communication needs that have been met by the massive expansion of WM (white matter). Damage to WM alters brain function, and numerous neurological diseases feature WM involvement. In the current review, we discuss the major features of WM, the contributions of WM compromise to brain pathophysiology, and some of the mechanisms mediating WM injury. We will emphasize the newly appreciated importance of… CONTINUE READING

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