Roles of voltage-dependent sodium channels in neuronal development, pain, and neurodegeneration.

  title={Roles of voltage-dependent sodium channels in neuronal development, pain, and neurodegeneration.},
  author={Akihiko Wada},
  journal={Journal of pharmacological sciences},
  volume={102 3},
  • Akihiko Wada
  • Published 2006 in Journal of pharmacological sciences
Besides initiating and propagating action potentials in established neuronal circuits, voltage-dependent sodium channels sculpt and bolster the functional neuronal network from early in embryonic development through adulthood (e.g., differentiation of oligodendrocyte precursor cells into oligodendrocytes, myelinating axon; competition between neighboring equipotential neurites for development into a single axon; enhancing and opposing functional interactions with attractive and repulsive… CONTINUE READING


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