Corpus ID: 19506157

Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing.

@article{Bourre2004RolesOU,
  title={Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing.},
  author={J. Bourre},
  journal={The journal of nutrition, health \& aging},
  year={2004},
  volume={8 3},
  pages={
          163-74
        }
}
  • J. Bourre
  • Published 2004
  • Medicine
  • The journal of nutrition, health & aging
Among various organs, in the brain, the fatty acids most extensively studied are omega-3 fatty acids. Alpha-linolenic acid (18:3omega3) deficiency alters the structure and function of membranes and induces minor cerebral dysfunctions, as demonstrated in animal models and subsequently in human infants. Even though the brain is materially an organ like any other, that is to say elaborated from substances present in the diet (sometimes exclusively), for long it was not accepted that food can have… Expand

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References

SHOWING 1-10 OF 197 REFERENCES
Essential fatty acids and the brain: possible health implications
TLDR
It may be that an optimal diet with a balance of n‐6 and n‐3 fatty acids may help to delay their onset or reduce the insult to brain functions which these diseases elicit. Expand
The fatty acid composition of subcellular membranes of rat liver, heart, and brain: diet-induced modifications.
TLDR
It has been found that each organelle has its own peculiar composition in fatty acids, which may be profoundly influenced by the diet, but to different degrees in different organelles. Expand
Lipid alterations and their reversion in the central nervous system of growing rats deficient in essential fatty acids
TLDR
Brain lipid analyses, carried out at various time intervals in EFA deficient animals, indicate that brain weights are already reduced in 10-day-old deficient rats, that brain phospholipids decrease, especially in the males after three months, and that fatty acid distribution changes begin rather early. Expand
Glucose transport and utilization are altered in the brain of rats deficient in n‐3 polyunsaturated fatty acids
TLDR
The present results suggest that changes in energy metabolism induced by n‐3 deficiency could result from functional alteration in glucose transporters. Expand
The metabolism and availability of essential fatty acids in animal and human tissues.
TLDR
Liver is one of the most active organs and its role is critical in providing less active tissues, particularly the brain, with long-chain PUFA secreted in VLDL (very low density lipoprotein). Expand
Long‐chain polyunsaturated fatty acids in human milk and brain growth during early infancy
TLDR
The ratio between arachidonic acid and docosahex‐aenoic acid in the milk from Swedish mothers is approximately the same as in the brain of infants, and was found to be positively correlated with the rate of gain of the occipito‐frontal head circumference and of the calculated brain weight at 1 mo and 3 mo of age. Expand
Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation.
TLDR
There was a regional distribution of the fatty acids in the brain and the impact of deficiency in alpha-linolenic acid was region-specific and Dietary egg yolk or cerebral phospholipids are an effective source of n-3 PUFA for the recovery of altered fatty acid composition induced by a diet deficient in n- 3 PUFA. Expand
trans fatty acids, 5. Fatty acid composition of lipids of the brain and other organs in suckling piglets
TLDR
The overall conclusion was that dietarytrans fatty acids had no noticeable effect on the brain PE composition but slight to moderate effects on the fatty acid profile of other organs of suckling piglets. Expand
The role of polyunsaturated fatty acids in restoring the aging neuronal membrane
TLDR
A central focus of this review is that a specific ratio of n-3/n-6 PUFA can restore many of these age-related effects, including long-term potentiation, that are lost during aging. Expand
Alteration of brain and liver microsomal polyunsaturated fatty acids following dietary vitamin E deficiency
TLDR
It is concluded that vitamin E may alter the enzymatic activities of chain elongation-desaturation and the relationship between vitamin E and PUFA in brain and liver microsomes. Expand
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