• Corpus ID: 19506157

Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing.

@article{Bourre2004RolesOU,
  title={Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing.},
  author={J. M. Bourre},
  journal={The journal of nutrition, health \& aging},
  year={2004},
  volume={8 3},
  pages={
          163-74
        }
}
  • J. Bourre
  • Published 2004
  • Biology, Medicine
  • The journal of nutrition, health & aging
Among various organs, in the brain, the fatty acids most extensively studied are omega-3 fatty acids. Alpha-linolenic acid (18:3omega3) deficiency alters the structure and function of membranes and induces minor cerebral dysfunctions, as demonstrated in animal models and subsequently in human infants. Even though the brain is materially an organ like any other, that is to say elaborated from substances present in the diet (sometimes exclusively), for long it was not accepted that food can have… 

Figures and Tables from this paper

Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2 : macronutrients.
  • J. Bourre
  • Medicine, Biology
    The journal of nutrition, health & aging
  • 2006
TLDR
Findings show that dietary factors play major roles in determining whether the brain age successfully of experiences neurodegenerative disorders, and the regulation of glycaemia improves the quality and duration of intellectual performance.
Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients.
  • J. Bourre
  • Medicine, Biology
    The journal of nutrition, health & aging
  • 2006
The objective of this update is to give an overview of the effects of dietary nutrients on the structure and certain functions of the brain. As any other organ, the brain is elaborated from
Dietary omega-3 Fatty acids and psychiatry: mood, behaviour, stress, depression, dementia and aging.
TLDR
Findings indicated that the nature of poly unsaturated fatty acids present in formula milks for infants determines the visual, cerebral, and intellectual abilities, as described in a recent review.
Dietary omega-3 Fatty acids and psychiatry: mood, behaviour, stress, depression, dementia and aging.
  • J. Bourre
  • Psychology, Medicine
    The journal of nutrition, health & aging
  • 2005
TLDR
Findings indicated that the nature of poly unsaturated fatty acids present in formula milks for infants determines the visual, cerebral, and intellectual abilities, as described in a recent review.
Plant derived omega-3-fatty acids protect mitochondrial function in the brain.
Where to find omega-3 fatty acids and how feeding animals with diet enriched in omega-3 fatty acids to increase nutritional value of derived products for human: what is actually useful ?
  • J. Bourre
  • Medicine
    The journal of nutrition, health & aging
  • 2005
TLDR
Omega-3 polyunsaturated fatty acids are very important to ensure brain structure and function, more specifically during development and aging, and concerning essential alpha-linolenic acid (ALA), most occidental diets contain about 50 % of the recommended dietary allowances.
The multiple roles of fatty acid handling proteins in brain
TLDR
This review will primarily focus on the recent studies that have highlighted the crucial role of lipid handling proteins in brain FA transport, neuronal differentiation and development, cognitive processes and brain diseases.
Effects of Diets High in Unsaturated Fatty Acids on Socially Induced Stress Responses in Guinea Pigs
TLDR
Omega-3 and omega-6 polyunsaturated fatty acids can diminish behavioral and physiological stress responses to the social environment, enabling individuals to cope with social stressors, but at the expense of plasma derived omega-3 fatty acids.
Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview
...
...

References

SHOWING 1-10 OF 197 REFERENCES
Essential fatty acids and the brain: possible health implications
The fatty acid composition of subcellular membranes of rat liver, heart, and brain: diet-induced modifications.
TLDR
It has been found that each organelle has its own peculiar composition in fatty acids, which may be profoundly influenced by the diet, but to different degrees in different organelles.
Lipid alterations and their reversion in the central nervous system of growing rats deficient in essential fatty acids
TLDR
Brain lipid analyses, carried out at various time intervals in EFA deficient animals, indicate that brain weights are already reduced in 10-day-old deficient rats, that brain phospholipids decrease, especially in the males after three months, and that fatty acid distribution changes begin rather early.
Glucose transport and utilization are altered in the brain of rats deficient in n‐3 polyunsaturated fatty acids
TLDR
The present results suggest that changes in energy metabolism induced by n‐3 deficiency could result from functional alteration in glucose transporters.
The metabolism and availability of essential fatty acids in animal and human tissues.
TLDR
Liver is one of the most active organs and its role is critical in providing less active tissues, particularly the brain, with long-chain PUFA secreted in VLDL (very low density lipoprotein).
Long‐chain polyunsaturated fatty acids in human milk and brain growth during early infancy
TLDR
The ratio between arachidonic acid and docosahex‐aenoic acid in the milk from Swedish mothers is approximately the same as in the brain of infants, and was found to be positively correlated with the rate of gain of the occipito‐frontal head circumference and of the calculated brain weight at 1 mo and 3 mo of age.
Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation.
TLDR
There was a regional distribution of the fatty acids in the brain and the impact of deficiency in alpha-linolenic acid was region-specific and Dietary egg yolk or cerebral phospholipids are an effective source of n-3 PUFA for the recovery of altered fatty acid composition induced by a diet deficient in n- 3 PUFA.
trans fatty acids, 5. Fatty acid composition of lipids of the brain and other organs in suckling piglets
TLDR
The overall conclusion was that dietarytrans fatty acids had no noticeable effect on the brain PE composition but slight to moderate effects on the fatty acid profile of other organs of suckling piglets.
Alteration of brain and liver microsomal polyunsaturated fatty acids following dietary vitamin E deficiency
...
...