Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness.

@article{Sung2015RolesOU,
  title={Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness.},
  author={Pil Soo Sung and Hyeonjoo Cheon and Chung Hwan Cho and Seon-Hui Hong and Do Youn Park and Hyung-Il Seo and Su-Hyung Park and Seung Kew Yoon and George R Stark and Eui-Cheol Shin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 33},
  pages={
          10443-8
        }
}
Up-regulation of IFN-stimulated genes (ISGs) is sustained in hepatitis C virus (HCV)-infected livers. Here, we investigated the mechanism of prolonged ISG expression and its role in IFN responsiveness during HCV infection in relation to unphosphorylated IFN-stimulated gene factor 3 (U-ISGF3), recently identified as a tripartite transcription factor formed by high levels of IFN response factor 9 (IRF9), STAT1, and STAT2 without tyrosine phosphorylation of the STATs. The level of U-ISGF3, but not… CONTINUE READING

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