Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment.

@article{Malhotra2013RolesOT,
  title={Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment.},
  author={Sunny Malhotra and Carlos Morcillo-Suarez and Ramil Nurtdinov and J. Amor R{\'i}o and Eduardo Tolosa Sarr{\'o} and Mireia Moreno and Juan-R. Castillo and Alfons Navarro and Xavier Montalban and Manuel Comabella},
  journal={European journal of neurology},
  year={2013},
  volume={20 10},
  pages={
          1390-7
        }
}
BACKGROUND AND PURPOSE Ubiquitin specific peptidase 18 (USP18) is a deubiquitinating enzyme that functions as a negative regulator of the type I interferon (IFN) signalling pathway and is specifically induced by type I IFNs. In the present study, previous observations by our group were expanded suggesting an implication of USP18 in multiple sclerosis (MS) based on the finding of a deficient expression of the gene in peripheral blood mononuclear cells from MS patients compared with healthy… CONTINUE READING
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