Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors.

Abstract

Somatic angiotensin-converting enzyme (ACE) contains two homologous domains, each bearing a functional active site. The in vivo contribution of each active site to the release of angiotensin II (Ang II) and the inactivation of bradykinin (BK) is still unknown. To gain insights into the functional roles of these two active sites, the in vitro and in vivo… (More)

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@article{Georgiadis2003RolesOT, title={Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors.}, author={Dimitris Georgiadis and Fabrice Beau and Bertrand Czarny and J{\"{o}el Cotton and Athanasios Yiotakis and Vincent Dive}, journal={Circulation research}, year={2003}, volume={93 2}, pages={148-54} }