Roles of the three major phosphorylation sites of hepatitis B virus core protein in viral replication.

@article{Lan1999RolesOT,
  title={Roles of the three major phosphorylation sites of hepatitis B virus core protein in viral replication.},
  author={Y T Lan and Jisu Li and Wei Liao and Jing-hsiung Ou},
  journal={Virology},
  year={1999},
  volume={259 2},
  pages={342-8}
}
Hepatitis B virus (HBV) core protein is a phosphoprotein. Its three major phosphorylation sites have been identified at the serine residues located at amino acids 157, 164, and 172. In order to investigate the role of core protein phosphorylation in HBV replication, these three serine residues were mutated to alanine to mimic nonphosphorylated serine or to glutamic acid to mimic phosphoserine. The nonphosphorylated core protein analog did not package the HBV pregenomic RNA, and the… CONTINUE READING

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