Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation.

@article{Hanley2010RolesOT,
  title={Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation.},
  author={Laura L Hanley and David R McGivern and Michael N. Teng and Robin Djang and Peter L. Collins and Rachel Fearns},
  journal={Virology},
  year={2010},
  volume={406 2},
  pages={241-52}
}
The 5' extragenic trailer region of respiratory syncytial virus (RSV) is known to be necessary for genome replication, but is more than three times the length of the 3' leader replication promoter, raising the possibility that trailer might play an additional role in viral replication. To examine this, mutant recombinant viruses were constructed in which the trailer region was truncated or substituted with leader-complement sequence. This analysis showed that the complete trailer increased… CONTINUE READING
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