Roles of the nucleational core complex and collagens (types II and X) in calcification of growth plate cartilage matrix vesicles.

@article{Kirsch1994RolesOT,
  title={Roles of the nucleational core complex and collagens (types II and X) in calcification of growth plate cartilage matrix vesicles.},
  author={Therese L Kirsch and Yoshinobu Ishikawa and Fackson Mwale and Roy E. Wuthier},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 31},
  pages={20103-9}
}
Matrix vesicles (MV) were shown to initiate mineralization in cartilage and other vertebrate tissues. However, the factors that drive this process remain to be fully elucidated. Recent studies have shown that a preformed nucleational core consisting mainly of a Ca(2+)-phosphatidylserine-Pi complex, is necessary for the accumulation of Ca2+ by MV. In addition, the collagens attached to the MV surface were shown to play an important role in stimulating Ca2+ uptake. In this study, we extend this… CONTINUE READING

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