Roles of the metallothionein family of proteins in the central nervous system

@article{Hidalgo2001RolesOT,
  title={Roles of the metallothionein family of proteins in the central nervous system},
  author={Juan Hidalgo and Michael Aschner and Paolo Zatta and Milan Va{\vs}{\'a}k},
  journal={Brain Research Bulletin},
  year={2001},
  volume={55},
  pages={133-145}
}
Metallothioneins (MTs) constitute a family of proteins characterized by a high heavy metal [Zn(II), Cu(I)] content and also by an unusual cysteine abundance. Mammalian MTs are comprised of four major isoforms designated MT-1 trough MT-4. MT-1 and MT-2 are expressed in most tissues including the brain, whereas MT-3 (also called growth inhibitory factor) and MT-4 are expressed predominantly in the central nervous system and in keratinizing epithelia, respectively. All MT isoforms have been… CONTINUE READING
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