Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

@article{Pirkkala2001RolesOT,
  title={Roles of the heat shock transcription factors in regulation of the heat shock response and beyond},
  author={Lila Pirkkala and P{\"a}ivi Nyk{\"a}nen and Lea Sistonen},
  journal={The FASEB Journal},
  year={2001},
  volume={15},
  pages={1118 - 1131}
}
The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival and death. In addition to extracellular stimuli… 
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Regulation of the heat shock response by heat shock transcription factors
TLDR
The current knowledge of the transcriptional regulation of the heat shock response is summarized, highlighting recent advances in exploring the multi-faceted nature of heat shock transcription.
Heat Shock Factor 2 (HSF2) Contributes to Inducible Expression of hsp Genes through Interplay with HSF1*
TLDR
It is demonstrated on chromatin that both HSF1 and HSF2 were able to bind the hsp70 promoter not only in response to heat shock but also during hemin-induced differentiation of K562 erythroleukemia cells, suggesting that HSF 1 influences the DNA binding activity of HSF 2.
The heat shock factor family and adaptation to proteotoxic stress
TLDR
The heat shock response regulated by the HSF family should consist of the induction of classical as well as of nonclassical heat shock genes, both of which might be required to maintain protein homeostasis.
Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2
TLDR
It is shown, using a novel DNA binding and detection assay, that HSF1 and HSF2 are coactivated to different levels in response to a range of conditions that cause cell stress and suggests a role for heat shock proteins in the positive regulation of HSF 2.
Hyperthermia Stress Activates Heat Shock Protein Expression via Propyl Isomerase 1 Regulation with Heat Shock Factor 1
TLDR
A novel role for PIN1 is proposed whereby it acts as a stress sensor regulating HSF1 activity in response to stress on multiple levels through the transcriptional activation of stress response elements in embryonic fibroblast cells, tumor cells, and neurons.
The regulation and function of the heat shock response
TLDR
The stress-sensing mechanisms that regulate HSFs and the role of post-translational modifications that regulateHSF activity are examined and the expression of molecular chaperones and heat shock genes is examined.
Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.
TLDR
It is demonstrated that recombinant mammalian HSF1 directly senses both heat and hydrogen peroxide to assemble into a homotrimer in a reversible and redox-regulated manner.
Changes in heat shock duration influence regulatory schemes of HSF1 activity
TLDR
Computational analysis of regulatory changes induced by different duration time of the heat shock condition in U2-OS wild type cells suggests different regulatory strategies in reaction to longer or shorter stress conditions, which is concluded to be an effect of transition between mild and severe stress.
Stress-Induced Expression of Heat Shock Proteins and Action of the Heat Shock Protein Effectors
TLDR
The heat shock response can be conveniently considered as a “sensing” circuitry that mounts a transcriptional response to imposed stress, and an “effector” arm consisting of a variety of actions mediated by the heat shock proteins.
Induction of Heat Shock Proteins by Hyperthermia and Noise Overstimulation in Hsf1−/− Mice
TLDR
Noise exposure conditions induced genes for several immediate early transcription factors and maximum induction occurred earlier than for heat shock proteins, indicating additional signaling pathways and transcriptional regulators that are activated by noise probably contribute to induction of heatshock proteins in the cochlea.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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