Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.

@article{Momcilovic2008RolesOT,
  title={Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.},
  author={Milica Momcilovic and Surtaj Hussain Iram and Yang Liu and M. Carlson},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 28},
  pages={19521-9}
}
The SNF1/AMP-activated protein kinase (AMPK) family is required for adaptation to metabolic stress and energy homeostasis. The gamma subunit of AMPK binds AMP and ATP, and mutations that affect binding cause human disease. We have here addressed the role of the Snf4 (gamma) subunit in regulating SNF1 protein kinase in response to glucose availability in Saccharomyces cerevisiae. Previous studies of mutant cells lacking Snf4 suggested that Snf4 counteracts autoinhibition by the C-terminal… CONTINUE READING