Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses.

@article{Kim2011RolesOT,
  title={Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses.},
  author={Shin-Hee Kim and Madhuri Subbiah and Arthur S. Samuel and Peter L. Collins and Siba K Samal},
  journal={Journal of virology},
  year={2011},
  volume={85 17},
  pages={
          8582-96
        }
}
Virulent and moderately virulent strains of Newcastle disease virus (NDV), representing avian paramyxovirus serotype 1 (APMV-1), cause respiratory and neurological disease in chickens and other species of birds. In contrast, APMV-2 is avirulent in chickens. We investigated the role of the fusion (F) and hemagglutinin-neuraminidase (HN) envelope glycoproteins in these contrasting phenotypes by designing chimeric viruses in which the F and HN glycoproteins or their ectodomains were exchanged… CONTINUE READING
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