Roles of the epoxygenase CYP2J2 in the endothelium.

@article{Askari2013RolesOT,
  title={Roles of the epoxygenase CYP2J2 in the endothelium.},
  author={Ara A. Askari and Scott John Peter Thomson and Matthew L Edin and Darryl C. Zeldin and David Bishop-Bailey},
  journal={Prostaglandins & other lipid mediators},
  year={2013},
  volume={107},
  pages={
          56-63
        }
}
Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are inactivated by soluble epoxide hydrolase (sEH), which converts them in to their corresponding dihydroxyeicosatrienoic acids (DHETs). CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells. CYP2J2 and the EETs it produces have been shown to have a diverse range of effects on the vasculature, including the regulation of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Similar Papers

Loading similar papers…