Roles of the cation–chloride cotransporters in neurological disease

@article{Kahle2008RolesOT,
  title={Roles of the cation–chloride cotransporters in neurological disease},
  author={Kristopher T. Kahle and Kevin J. Staley and Brian V. Nahed and Gerardo Gamba and Steven C. Hebert and Richard P Lifton and David B. Mount},
  journal={Nature Clinical Practice Neurology},
  year={2008},
  volume={4},
  pages={490-503}
}
In the nervous system, the intracellular chloride concentration ([Cl−]i) determines the strength and polarity of γ-aminobutyric acid (GABA)-mediated neurotransmission. [Cl−]i is determined, in part, by the activities of the SLC12 cation–chloride cotransporters (CCCs). These transporters include the Na–K–2Cl cotransporter NKCC1, which mediates chloride influx, and various K–Cl cotransporters—such as KCC2 and KCC3—that extrude chloride. A precise balance between NKCC1 and KCC2 activity is… Expand
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TLDR
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TLDR
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