Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain.

@article{Ohtsuka2001RolesOT,
  title={Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain.},
  author={Toshiyuki Ohtsuka and Masami Sakamoto and François Guillemot and Ryoichiro Kageyama},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={30467-74}
}
Neural stem cells, which differentiate into neurons and glia, are present in the ventricular zone of the embryonal brain. The precise mechanism by which neural stem cells are maintained during embryogenesis remains to be determined. Here, we found that transient misexpression of the basic helix-loop-helix genes Hes1 and Hes5 keeps embryonal telencephalic cells undifferentiated although they have been shown to induce gliogenesis in the retina. These telencephalic cells later differentiate into… CONTINUE READING
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Development

  • J Hatakeyama, K Tomita, T Inoue, R Kageyama
  • Development
  • 2001

Nature

  • S Noctor, A C Flint, T A Weissman, R S Dammerman, A R Friegstein
  • Nature
  • 2001

Embo J

  • K Tomita, K Moriyoshi, S Nakanishi, F Guillemot, R Kageyama
  • EMBO J
  • 2000

J. Biol. Chem

  • H Hirata, T Ohtsuka, Y Bessho, R Kageyama
  • J. Biol. Chem
  • 2000

J. Neurosci

  • Y Nakamura, S Sakakibara, +5 authors H Okano
  • J. Neurosci
  • 2000

Mol. Cell. Biol

  • P Castella, S Sawai, K Nakao, J A Wagner, M Caudy
  • Mol. Cell. Biol
  • 2000

Cell

  • F Doetsch, I Caillé, D A Lim, J M García-Verdugo, A Alvarez-Buylla
  • Cell
  • 1999

Cell. Mol. Biol

  • T Allen, C G Lobe
  • Cell. Mol. Biol
  • 1999

Dev. Growth Differ

  • J Funahashi, T Okafuji, H Ohuchi, S Noji, H Tanaka, H Nakamura
  • Dev. Growth Differ
  • 1999

J. Neurosci. Res

  • P Castella, J A Wagner, M Caudy
  • J. Neurosci. Res
  • 1999

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