Roles of the amino acid side chains in the actin-binding S-site of myosin heavy chain.

@article{Eto1990RolesOT,
  title={Roles of the amino acid side chains in the actin-binding S-site of myosin heavy chain.},
  author={Masumi Eto and Ryuji Suzuki and F Morita and Hideki Kuwayama and Nozomu Nishi and Seiichi Tokura},
  journal={Journal of biochemistry},
  year={1990},
  volume={108 3},
  pages={499-504}
}
The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-OEt is the analog of the S-site, one of the actin-binding sites in myosin [Suzuki et al. (1987) J. Biol. Chem. 262, 11410-11412]. Various substituted heptapeptides were synthesized, and the dissociation constants of each acto-heptapeptide complex was measured. Comparison of the dissociation constants indicated… CONTINUE READING