Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection.

@article{Regoes2004RolesOT,
  title={Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection.},
  author={Roland R. Regoes and Rustom Antia and David A. Garber and Guido Silvestri and Mark B. Feinberg and Silvija I. Staprans},
  journal={Journal of virology},
  year={2004},
  volume={78 9},
  pages={4866-75}
}
There is an ongoing debate on whether acute human immunodeficiency virus infection is controlled by target cell limitation or by virus-specific cellular immunity. To resolve this question, we developed a novel mathematical modeling scheme which allows us to incorporate measurements of virus load, target cells, and virus-specific immunity and applied it to a comprehensive data set generated in an experiment involving rhesus macaques infected with simian immunodeficiency virus. Half of the… CONTINUE READING