Roles of sulfated glycans in lymphocyte homing.

  title={Roles of sulfated glycans in lymphocyte homing.},
  author={Hiroto Kawashima},
  journal={Biological & pharmaceutical bulletin},
  volume={29 12},
Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands, which are expressed on high endothelial venules (HEV) in the lymph nodes. To examine the significance of the sulfation of L-selectin ligands, our group has generated gene-targeted mice deficient in both N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST)-1 and GlcNAc6ST-2. The mutant mice show approximately 75% less lymphocyte homing to the peripheral… CONTINUE READING


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