Roles of stress-activated protein kinases in the replication of Singapore grouper iridovirus and regulation of the inflammatory responses in grouper cells.

@article{Huang2011RolesOS,
  title={Roles of stress-activated protein kinases in the replication of Singapore grouper iridovirus and regulation of the inflammatory responses in grouper cells.},
  author={Xiaohong Huang and Youhua Huang and Zhengliang Ouyang and J Cai and Yang Yan and Q Qin},
  journal={The Journal of general virology},
  year={2011},
  volume={92 Pt 6},
  pages={1292-301}
}
Stress-activated protein kinases (SAPKs), including p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (JNK), are usually activated in response to different environmental stimuli, including virus infection. In the present study, the roles of SAPKs during Singapore grouper iridovirus (SGIV) infection were investigated in fish cells. The results showed that increased phosphorylation of JNK1/2 and p38 MAPK occurred during active replication of SGIV in grouper cell cultures… CONTINUE READING

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