Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis.

@article{McCubrey2015RolesOS,
  title={Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis.},
  author={James Andrew McCubrey and Stephen L. Abrams and Timothy L Fitzgerald and Lucio Cocco and Alberto Maria Martelli and Giuseppe Montalto and Melchiorre Cervello and Aurora Scalisi and Saverio Candido and Massimo Libra and Linda S. Steelman},
  journal={Advances in biological regulation},
  year={2015},
  volume={57},
  pages={75-101}
}
The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance, cancer initiating cells (CICs) and metastasis. The expression of this pathway is frequently altered in breast and other cancers due to mutations at or aberrant expression of: HER2, EGFR1, PIK3CA, and PTEN as well as other… CONTINUE READING