Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073.

Abstract

A D-serine deaminase (DsdA) mutant of uropathogenic Escherichia coli strain CFT073 has a hypercolonization phenotype in a murine model of urinary tract infection (UTI) due to increased virulence gene expression by an unknown mechanism (B. J. Haugen et al., Infect. Immun. 75:278-289, 2007). DsdC is a D-serine-dependent activator of dsdXA transcription. DsdC… (More)

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@article{Anfora2007RolesOS, title={Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073.}, author={Andrew T Anfora and Brian J Haugen and Paula L. Roesch and Peter Redford and Rodney A. Welch}, journal={Infection and immunity}, year={2007}, volume={75 11}, pages={5298-304} }