Roles of selection and recombination in the evolution of type I restriction-modification systems in enterobacteria.

@article{Sharp1992RolesOS,
  title={Roles of selection and recombination in the evolution of type I restriction-modification systems in enterobacteria.},
  author={Paul M Sharp and J E Kelleher and Agyirifo S Daniel and Graeme J. M. Cowan and Noreen E. Murray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 20},
  pages={9836-40}
}
Restriction-modification systems can protect bacteria against viral infection. Sequences of the hsdM gene, encoding one of the three subunits of type I restriction-modification systems, have been determined for four strains of enterobacteria. Comparison with the known sequences of EcoK and EcoR124 indicates that all are homologous, though they fall into three families (exemplified by EcoK, EcoA, and EcoR124), the first two of which are apparently allelic. The extent of amino acid sequence… CONTINUE READING