Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis

@article{Suzuki2015RolesOR,
  title={Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis},
  author={Norio Suzuki and Masayuki Yamamoto},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2015},
  volume={468},
  pages={3-12}
}
Erythropoietic induction is critical for enhancing the efficiency of oxygen delivery during the chronic phase of the systemic hypoxia response. The erythroid growth factor erythropoietin (Epo) triggers the erythropoietic induction through the activation of erythroid genes related to cell survival, differentiation, and iron metabolism. Because Epo is produced in renal Epo-producing (REP) cells in a hypoxia-inducible manner, REP cells serve as a control center for the systemic hypoxia response… CONTINUE READING
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