Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-induced nephropathy.

@article{Ohtake1997RolesOR,
  title={Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-induced nephropathy.},
  author={Takayasu Ohtake and Masato Kimura and Masataka Nishimura and Akira Hishida},
  journal={The Journal of laboratory and clinical medicine},
  year={1997},
  volume={129 1},
  pages={
          81-8
        }
}
  • Takayasu Ohtake, Masato Kimura, +1 author Akira Hishida
  • Published in
    The Journal of laboratory and…
    1997
  • Chemistry, Medicine
  • We evaluated the roles of reactive oxygen species and intrinsic antioxidant enzymes in the development of daunomycin (DM)-induced nephropathy in mice. A single dose of DM (20 mg/kg intravenously) induced proteinuria by day 7 and the nephrotic syndrome by day 14 in DM-sensitive strain (A/J) but not in DM-resistant strain (C57BL/6J) (B6). Renal cortical lipid peroxide levels in the A/J mice significantly increased at days 2, 4, and 7 after DM injection, whereas no increase was observed in the B6… CONTINUE READING

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