Roles of reactive oxygen and nitrogen species in pain.


Peroxynitrite (PN; ONOO⁻) and its reactive oxygen precursor superoxide (SO; O₂•⁻) are critically important in the development of pain of several etiologies including pain associated with chronic use of opiates such as morphine (also known as opiate-induced hyperalgesia and antinociceptive tolerance). This is now an emerging field in which considerable… (More)
DOI: 10.1016/j.freeradbiomed.2011.01.026


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@article{Salvemini2011RolesOR, title={Roles of reactive oxygen and nitrogen species in pain.}, author={Daniela Salvemini and Joshua W. Little and Timothy M. Doyle and William L. Neumann}, journal={Free radical biology & medicine}, year={2011}, volume={51 5}, pages={951-66} }