Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors.

@article{Fuhrer1999RolesOR,
  title={Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors.},
  author={Christian Fuhrer and Medha Gautam and J E Sugiyama and Zach W. Hall},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 15},
  pages={6405-16}
}
At the neuromuscular junction, aggregates of acetylcholine receptors (AChRs) are anchored in the muscle membrane by association with rapsyn and other postsynaptic proteins. We have investigated the interactions between the AChR and these proteins in cultured C2 myotubes before and after treatment with agrin, a nerve-derived protein that induces AChRs to cluster. When AChRs were isolated from detergent extracts of untreated C2 myotubes, they were associated with rapsyn and, to a lesser degree… CONTINUE READING

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