Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein.

@article{Hooper2005RolesOP,
  title={Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein.},
  author={Nigel M. Hooper},
  journal={Biochemical Society transactions},
  year={2005},
  volume={33 Pt 2},
  pages={
          335-8
        }
}
  • N. Hooper
  • Published 1 April 2005
  • Biology
  • Biochemical Society transactions
In the amyloidogenic pathway, the APP (amyloid precursor protein) is proteolytically processed by the beta- and gamma-secretases to release the Abeta (amyloid-beta) peptide that is neurotoxic and aggregates in the brains of patients suffering from Alzheimer's disease. In the non-amyloidogenic pathway, APP is cleaved by alpha-secretase within the Abeta domain, precluding deposition of intact Abeta peptide. The cellular form of the PrP(C) (prion protein) undergoes reactive oxygen species-mediated… 

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