Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes.

@article{Tsuruda2001RolesOP,
  title={Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes.},
  author={Toshihiro Tsuruda and Johji Kato and Kazuo Kitamura and Kazuto Mishima and Takuroh Imamura and Yasushi Koiwaya and Kenji Kangawa and Tanenao Eto},
  journal={Journal of hypertension},
  year={2001},
  volume={19 4},
  pages={
          757-63
        }
}
OBJECTIVES We showed that angiotensin II stimulates adrenomedullin production in cultured neonatal rat cardiac myocytes, and that the secreted adrenomedullin inhibits hypertrophy of the myocytes, although the intracellular mechanisms of adrenomedullin production are still unknown. Since protein kinase C (PKC) and the Ca2+ signaling system are involved in cardiac hypertrophy, we examined the roles of these intracellular signaling systems in the production of adrenomedullin by myocytes. METHODS… CONTINUE READING
BETA