Roles of protein kinase B/Akt in lung cancer.

@article{Xu2010RolesOP,
  title={Roles of protein kinase B/Akt in lung cancer.},
  author={Cheng-Xiong Xu and Hua Jin and J Y Shin and Ji-Eun Kim and M. -Il Cho},
  journal={Frontiers in bioscience},
  year={2010},
  volume={2},
  pages={1472-84}
}
Lung cancer is the leading cause of cancer-related death worldwide and has frequently been associated with over-activated protein kinase B (PKB)/Akt. Akt is a serine/threonine protein kinase that plays an important role in cell growth, proliferation, and survival. Many lines of evidence point to the contribution of deregulated Akt in development or progression of lung cancer. In addition, recent studies have demonstrated that cancer cells defend themselves from therapeutic treatment through… CONTINUE READING

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