Roles of prostaglandins in tumor-associated lymphangiogenesis with special reference to breast cancer

@article{Lala2018RolesOP,
  title={Roles of prostaglandins in tumor-associated lymphangiogenesis with special reference to breast cancer},
  author={P. K. Lala and Pinki Nandi and Mousumi Majumder},
  journal={Cancer and Metastasis Reviews},
  year={2018},
  volume={37},
  pages={369-384}
}
Lymphangiogenesis (formation of new lymphatic vessels), unlike angiogenesis, has been a lesser-focused field in cancer biology, because of earlier controversy regarding whether lymphatic metastasis occurs via pre-existing or newly formed lymphatics. Recent evidence reveals that peri-tumoral or intra-tumoral lymphangiogenesis is a precursor for lymphatic metastasis in most carcinomas and melanomas. Two major lymphangiogenic factors, vascular endothelial growth factor (VEGF)-C and VEGF-D, are… CONTINUE READING
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