Roles of prostaglandin E receptors in stress responses.

  title={Roles of prostaglandin E receptors in stress responses.},
  author={Tomoyuki Furuyashiki and Shuh Narumiya},
  journal={Current opinion in pharmacology},
  volume={9 1},
Stress is a condition in which the body homeostasis is perturbed by various stimuli such as sickness and psychological stimuli. Stress evokes adaptive responses including febrile, neuroendocrine, and behavioral responses. Prostaglandin (PG) E(2) is a metabolite from arachidonic acid, and exerts its functions through G-protein-coupled receptors called EP1, EP2, EP3, and EP4. Recent studies using knockout mice and selective drugs revealed the roles of these receptors in stress responses. Upon… CONTINUE READING