Roles of phospholipid signaling in chemoattractant-induced responses.

@article{Wu2000RolesOP,
  title={Roles of phospholipid signaling in chemoattractant-induced responses.},
  author={Dianna Y. Wu and Christopher K Huang and Hong Jiang},
  journal={Journal of cell science},
  year={2000},
  volume={113 ( Pt 17)},
  pages={2935-40}
}
Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K). Recent studies of mouse lines that lack PLC-(beta)2, PLC-(beta)3, or PI3K(gamma) demonstrate that chemoattractants act through PLC-(beta)2 and PLC-(beta)3 to hydrolyze PtdIns(4,5)P… CONTINUE READING
41 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

The roles of phospholipase C

  • H. Jiang, Y. Kuang, M. I. Simon, D. Wu
  • 1997
Highly Influential
13 Excerpts

Chemokine-induced signal transduction in leukocytes

  • K. B. Bacon
  • Eur. Cytokine Network10,
  • 1999
Highly Influential
10 Excerpts

The roles of phospholipase C β 2 in chemoattractant - induced responses

  • H. Jiang, Y. Kuang, M. I. Simon, D. Wu
  • Proc . Nat . Acad . Sci USA
  • 1997
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…