Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.

@article{Rudge2004RolesOP,
  title={Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.},
  author={Simon A. Rudge and Vicki A. Sciorra and Michelle Iwamoto and Chun Zhou and Thomas Strahl and Andrew J. Morris and J. Thorner and JoAnne Engebrecht},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 1},
  pages={
          207-18
        }
}
During yeast sporulation, internal membrane synthesis ensures that each haploid nucleus is packaged into a spore. Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. We found that both meiosis and spore formation also require the phosphatidylinositol (PtdIns)/PtdCho transport protein Sec14p. Specific ablation of the PtdIns… CONTINUE READING

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Saccharomyces cerevisiae phospholipase D in sporulation and Sec14-independent secretion

  • S. A. Rudge, M. M. Cavenagh, +4 authors J. Engebrecht
  • Mol. Biol. Cell
  • 1998
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