Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.

  title={Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.},
  author={S. Rudge and V. A. Sciorra and M. Iwamoto and C. Zhou and T. Strahl and A. Morris and J. Thorner and J. Engebrecht},
  journal={Molecular biology of the cell},
  volume={15 1},
  • S. Rudge, V. A. Sciorra, +5 authors J. Engebrecht
  • Published 2004
  • Biology, Medicine
  • Molecular biology of the cell
  • During yeast sporulation, internal membrane synthesis ensures that each haploid nucleus is packaged into a spore. Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. We found that both meiosis and spore formation also require the phosphatidylinositol (PtdIns)/PtdCho transport protein Sec14p. Specific ablation of the PtdIns… CONTINUE READING
    Cytokinesis in yeast meiosis depends on the regulated removal of Ssp1p from the prospore membrane
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