Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.

@article{Ruan2017RolesOP,
  title={Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.},
  author={Lingling Ruan and Yanting Shen and Ziwen Lu and Dongsheng Shang and Zhicong Zhao and Yongjin Lu and Yanfang Wu and Yafei Zhang and Zhigang Tu and Hanqing Liu},
  journal={Clinical and experimental pharmacology & physiology},
  year={2017},
  volume={44 9},
  pages={909-913}
}
A pivotal regulator of cell polarity and homeostasis, partitioning-defective protein 6 (Par6) forms multicomponent complexes that not only regulate cell polarity and stabilize cell morphology, but have also been demonstrated to participate in the proliferation, migration and invasion of cancer cells. The transforming growth factor (TGF)-β and extracellular signal-regulated kinase (Erk) 1/2 pathways are the most thoroughly studied pathways involving Par6 in many cancers. Aurothiomalate has been… CONTINUE READING