Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis.

@article{Masamune2009RolesOP,
  title={Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis.},
  author={Atsushi Masamune and Takashi Watanabe and Kazuhiro Kikuta and Tooru Shimosegawa},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2009},
  volume={7 11 Suppl},
  pages={S48-54}
}
Over a decade, there is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic fibrosis. In response to pancreatic injury or inflammation, quiescent PSCs are transformed (activated) to myofibroblast-like cells, which express alpha-smooth muscle actin. Activated PSCs proliferate, migrate, produce extracellular matrix components, such as type I collagen, and express cytokines and chemokines. Recent studies have suggested novel… CONTINUE READING