Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr.

@article{Shostak1999RolesOP,
  title={Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr.},
  author={L D Shostak and John K Ludlow and John Fisk and S A Pursell and Bobbie J. Rimel and Duy Dieu Nguyen and Joseph D. Rosenblatt and Vicente Planelles},
  journal={Experimental cell research},
  year={1999},
  volume={251 1},
  pages={156-65}
}
The vpr gene from the human immunodeficiency virus type-1 (HIV-1) encodes a 14-kDa protein that prevents cell proliferation by causing a block in the G(2) phase of the cell cycle. This cellular function of vpr is conserved in evolution because other primate lentiviruses, including HIV-2, SIV(mac), and SIV(agm) encode related genes that also induce G(2) arrest. After G(2) arrest, cells expressing vpr undergo apoptosis. The signaling pathways that result in vpr-induced cell cycle arrest and… CONTINUE READING
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