Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation.

@article{Muschamp2013RolesON,
  title={Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation.},
  author={John W. Muschamp and William A Carlezon},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2013},
  volume={3 2},
  pages={a012005}
}
Psychostimulants such as amphetamine and cocaine are believed to produce dependence by causing rapid, supraphysiological elevations in synaptic dopamine (DA) within the nucleus accumbens (NAc) (Volkow et al. 2009, Neuropharmacology 56: 3-8). These changes in forebrain DA transmission are similar to those evoked by natural reinforcers (Louilot et al. 1991, Brain Res 553: 313-317; Roitman et al. 2004, J Neurosci 24: 1265-1271), but are of greater magnitude and longer duration. Repeated drug… CONTINUE READING
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