Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide.

@article{Minami1998RolesON,
  title={Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide.},
  author={Toshiaki Minami and Jiro Okazaki and Atsufumi Kawabata and Hideko Kawaki and Yuko Okazaki and Yoshiytiki Tohno},
  journal={Environmental toxicology and pharmacology},
  year={1998},
  volume={5 1},
  pages={
          35-41
        }
}
We investigated the involvement of nitric oxide (NO) and prostaglandins (PGs) in the damage to the blood-brain barrier (BBB) induced by lipopolysaccharide (LPS), using fluorescein as a tracer in mice. Aminoguanidine, a competitive inhibitor of inducible NO synthase (iNOS), when administered s.c. at 5 mg/kg, but not 500 mg/kg, reduced significantly the increase in brain fluorescein level after its i.v. injection in LPS-treated mice. When 1000 mg/kg of l-arginine, a substrate of NOS, were co… CONTINUE READING

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