Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension.

Abstract

We investigated vasodilator responses to acetylcholine (ACh) in isolated mesenteric vascular bed preparations (preconstricted with methoxamine) of young (2 months) and old (18 months) normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). ACh produced a similar dose-dependent vasorelaxant effect in preparations from both 2-month old… (More)

Topics

Cite this paper

@article{Mantelli1995RolesON, title={Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension.}, author={Luiz Rog{\'e}rio Mantelli and Sandra Amerini and Fernanda Ledda}, journal={Journal of cardiovascular pharmacology}, year={1995}, volume={25 4}, pages={595-602} }