Roles of molecular regions in determining differences between voltage dependence of activation of CaV3.1 and CaV1.2 calcium channels.

@article{Li2004RolesOM,
  title={Roles of molecular regions in determining differences between voltage dependence of activation of CaV3.1 and CaV1.2 calcium channels.},
  author={Junying Li and Louisa Stevens and Norbert Klugbauer and Dennis Wray},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={26858-67}
}
Voltage-dependent calcium channels are classified into low voltage-activated and high voltage-activated channels. We have investigated the molecular basis for this difference in voltage dependence of activation by constructing chimeras between a low voltage-activated channel (Ca(V)3.1) and a high voltage-activated channel (Ca(V)1.2), focusing on steady-state activation properties. Wild type and chimeras were expressed in oocytes, and two-electrode voltage clamp recordings were made of calcium… CONTINUE READING