Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).

@article{Nishikawa2005RolesOM,
  title={Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).},
  author={Shuh-ichi Nishikawa and Jeffrey L. Brodsky and Kunio Nakatsukasa},
  journal={Journal of biochemistry},
  year={2005},
  volume={137 5},
  pages={551-5}
}
Secreted proteins are synthesized at the endoplasmic reticulum (ER), and a quality control mechanism in the ER is essential to maintain secretory pathway homeostasis. Newly synthesized soluble and integral membrane secreted proteins fold into their native conformations with the aid of ER molecular chaperones before they are transported to post-ER… CONTINUE READING