Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice.

@article{Suzuki2002RolesOM,
  title={Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice.},
  author={Kazuo T. Suzuki and Akiyoshi Someya and Yoshiko Komada and Yasumitsu Ogra},
  journal={Journal of inorganic biochemistry},
  year={2002},
  volume={88 2},
  pages={173-82}
}
Metallothionein (MT) protects the body from both harmful non-essential and excessive essential metals. Copper (Cu) is an essential metal, and its concentration in the body is regulated at a constant level between excess and deficient ones. Cu accumulating in the livers of Wilson disease patients and its animal model, Long-Evans rats with a cinnamon-like coat color (LEC) rats, is in the form of Cu,Zn-MT, MT being an antioxidant. Contrary to the efficient production of MT in response to excessive… CONTINUE READING

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