Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

@article{Gialeli2011RolesOM,
  title={Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting},
  author={Chrisostomi Gialeli and Achilleas D. Theocharis and Nikos K. Karamanos},
  journal={The FEBS Journal},
  year={2011},
  volume={278}
}
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent extracellular matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as carcinogenesis. In this regard, their activity plays a pivotal role in tumor growth and the multistep processes of invasion and metastasis, including proteolytic degradation of ECM, alteration of the cell–cell and cell–ECM interactions, migration and angiogenesis. The underlying premise of the current minireview is… 
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This review focuses on the participation of both MMPs and TIMPs in physiological processes and on how their abnormal regulation is associated with human diseases.
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MMPs molecular characteristics, their synthesis regulation and enzymatic activity, their participation in the metastatic process, and how their functions have been used to improve cancer treatment are reviewed.
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The regulatory role of MMPs in cancer progression, current strategies in targeting MMP's for cancer treatment including prodrug design and tumor imaging, and therapeutic value of M MPs as biomarkers in breast, lung, and prostate cancers are discussed.
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