Roles of lipid polymorphism in intracellular delivery.

  title={Roles of lipid polymorphism in intracellular delivery.},
  author={Ismail M. Hafez and Pieter R Cullis},
  journal={Advanced drug delivery reviews},
  volume={47 2-3},
Lipids, which adopt nonbilayer phases, have fascinated researchers as to the functional roles of these components in biomembranes. In particular, lipids capable of adopting the hexagonal H(II) phase have received considerable attention because of the observation that such lipids can promote membrane fusion. In the rational design of lipid-based delivery systems, H(II) phase lipids have been employed to endow systems with fusogenic, membrane-destabilizing properties. We will outline the… CONTINUE READING

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