Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle.
@article{Macko2008RolesOI, title={Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle.}, author={A. Macko and Alan N. Beneze and M. K. Teachey and E. Henriksen}, journal={Archives of physiology and biochemistry}, year={2008}, volume={114 5}, pages={ 331-9 } }
We have demonstrated previously in insulin-sensitive skeletal muscle that lithium, an alkali metal and non-selective inhibitor of glycogen synthase kinase-3 (GSK-3), activates glucose transport by engaging the stress-activated p38 mitogen-activated protein kinase (p38 MAPK). However, it is presently unknown whether this same mechanism underlies lithium action on the glucose transport system in insulin-resistant skeletal muscle. We therefore assessed the effects of lithium on basal and insulin… CONTINUE READING
Topics from this paper
11 Citations
Attenuation of oxidant-induced muscle insulin resistance and p38 MAPK by exercise training.
- Medicine
- Free radical biology & medicine
- 2009
- 22
AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation
- Chemistry, Medicine
- Circulation research
- 2014
- 31
- PDF
Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents
- Biology, Medicine
- Archives of physiology and biochemistry
- 2010
- 7
Is phosphoadenosine phosphate phosphatase a target of lithium’s therapeutic effect?
- Chemistry, Medicine
- Journal of Neural Transmission
- 2009
- 7
Trace elements in glucometabolic disorders: an update
- Medicine
- Diabetology & metabolic syndrome
- 2010
- 125
Pharmacometabolomic Signature of Ataxia SCA1 Mouse Model and Lithium Effects
- Biology, Medicine
- PloS one
- 2013
- 10
- PDF
Phytochemical analysis and peripheral glucose utilization activity determination of Steblus asper
- Medicine
- 2012
- 2
Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer’s Disease Mortality in Texas
- Psychology, Medicine
- Journal of Alzheimer's disease : JAD
- 2018
- 22