Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle.

@article{Macko2008RolesOI,
  title={Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle.},
  author={A. Macko and Alan N. Beneze and M. K. Teachey and E. Henriksen},
  journal={Archives of physiology and biochemistry},
  year={2008},
  volume={114 5},
  pages={
          331-9
        }
}
  • A. Macko, Alan N. Beneze, +1 author E. Henriksen
  • Published 2008
  • Medicine
  • Archives of physiology and biochemistry
  • We have demonstrated previously in insulin-sensitive skeletal muscle that lithium, an alkali metal and non-selective inhibitor of glycogen synthase kinase-3 (GSK-3), activates glucose transport by engaging the stress-activated p38 mitogen-activated protein kinase (p38 MAPK). However, it is presently unknown whether this same mechanism underlies lithium action on the glucose transport system in insulin-resistant skeletal muscle. We therefore assessed the effects of lithium on basal and insulin… CONTINUE READING
    11 Citations
    Is phosphoadenosine phosphate phosphatase a target of lithium’s therapeutic effect?
    • 7
    The role of GSK-3β in notch signalling in vascular smooth muscle cells
    • PDF
    Bone Morphogenetic Protein 4 regulates white, beige and brown adipose tissue
    • PDF
    Trace elements in glucometabolic disorders: an update
    • 125