Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation.

@article{Guil2003RolesOH,
  title={Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation.},
  author={S{\`o}nia Guil and Renata Gattoni and Montserrat Carrascal and Joaquin Abian and James St{\'e}venin and Montse Bach-Elias},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 8},
  pages={2927-41}
}
Human ras genes play central roles in coupling extracellular signals with complex intracellular networks controlling proliferation, differentiation, and apoptosis, among others processes. c-H-ras pre-mRNA can be alternatively processed into two mRNAs due to the inclusion or exclusion of the alternative exon IDX; this renders two proteins, p21H-Ras and p19H-RasIDX, which differ only at the carboxy terminus. Here, we have characterized some of the cis-acting sequences and trans-acting factors… CONTINUE READING
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