Roles of histone acetyltransferases and deacetylases in gene regulation

@article{Kuo1998RolesOH,
  title={Roles of histone acetyltransferases and deacetylases in gene regulation},
  author={Min-Hao Kuo and C. David Allis},
  journal={BioEssays},
  year={1998},
  volume={20}
}
Acetylation of internal lysine residues of core histone N‐terminal domains has been found correlatively associated with transcriptional activation in eukaryotes for more than three decades. Recent discoveries showing that several transcriptional regulators possess intrinsic histone acetyltransferase (HAT) and deacetylase (HDAC) activities strongly suggest that histone acetylation and deacetylation each plays a causative role in regulating transcription. Intriguingly, several HATs have been… 

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  • R. Marmorstein
  • Biology, Chemistry
    Cellular and Molecular Life Sciences CMLS
  • 2001
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To fully appreciate the role of acetylation in transcription, the dynamic nature of this event must be understood.

Untargeted tail acetylation of histones in chromatin: lessons from yeast.

The current understanding of the mechanisms by which untargeted KAT and HDAC activities modulate the acetylation state of nucleosomal histones is reviewed, focusing on results obtained for H3 and H4 in budding yeast.

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Results indicate that HDAC8 is a novel member of the histone deacetylase family, which may play a role in the development of a broad range of tissues and potentially in the etiology of cancer.

Structure of histone acetyltransferases.

A comparison of structure determination of the divergent HAT enzymes Hat1, Gcn5/PCAF and Esa1 reveals a structurally conserved central core domain that mediates extensive interactions with the acetyl-coenzyme A cofactor, and structurally divergent N and C-terminal domains.
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